Manufacturing & Launch · Commercial Scale-Up & Manufacturing

Commercial scale-up, from pilot batch to full production.

We take your product from pilot to commercial volumes — selecting the right GMP-certified partner manufacturer, transferring the process and supporting the first production runs.

What We Do

Commercial Scale-Up & Manufacturing services.

From pilot batch to retail shelf — through Guires PNL and our network of GMP-certified partner manufacturers.

Manufacturer selection

GMP-certified partners matched to your format, volumes, markets and certifications.

Technology transfer

Formula, process parameters, specifications and quality checks handed over in full.

Scale-up trials

Trial runs on commercial equipment, compared against the pilot product.

Process validation

Kill-step, moisture and nutrient-retention checks for each format.

Release specifications

Finished-product specifications and batch release testing agreed.

First-run support

Our team supports the first production runs and resolves deviations.

Scientific Challenges

What we solve for.

01

Nutrient losses at scale

Retorting and extrusion reduce heat-sensitive vitamins and usable amino acids.

02

Safety after the kill step

Pathogens can recontaminate products during cooling, coating and packing.

03

Equipment differences

A recipe must be re-tuned for each manufacturer’s line.

04

Batch-to-batch consistency

Release testing confirms each run matches its label and specification.

How We Work

From question to evidence.

Assess

Format, volume and markets.

Match

Partner manufacturer selected.

Transfer

Formula and process handed over.

Trial

Commercial trial runs.

Validate

Safety and nutrient checks.

Launch

First production supported.

Evidence

The science behind our approach.

Peer-reviewed findings that shape how we design and interpret this work.

Peer-reviewed evidenceCommercial Scale-Up & Manufacturing · 1 source

Retorting destroys thiamin

Retorting cut thiamin in canned cat food by 30.4%, whatever the container; time to reach target lethality ranged from 29.5 to 45.6 minutes by pack size.
What we do

Vitamins are measured after processing, and heat penetration is studied for each pack format.

  1. StudyDainton 2023, Front Vet Sci
Peer-reviewed evidenceCommercial Scale-Up & Manufacturing · 2 sources

Recontamination after the kill step

Salmonella stayed detectable on dry pet food for 19 months; E. faecium is a conservative surrogate for validating heat steps.
What we do

Kill steps are validated with surrogates where needed, and post-process hygiene is part of the transfer package.

  1. StudyLambertini 2016, Food Microbiol
  2. StudyBianchini 2014, J Food Prot
Peer-reviewed evidenceCommercial Scale-Up & Manufacturing · 1 source

Heat reduces usable protein

In moist canned cat foods, on average 48.6% of lysine had undergone early Maillard reaction.
What we do

Processing losses are allowed for in the formula and checked on pilot product.

  1. Studyvan Rooijen 2013, Nutr Res Rev
Deliverables

What you take away.

  • Shortlist of matched partner manufacturers
  • Technology-transfer package
  • Scale-up trial report against the pilot product
  • Validated process and release specifications
  • Support for first commercial runs

Ingredient science for commercial scale-up & manufacturing

Every ingredient we choose for commercial scale-up & manufacturing is assessed for nutrient contribution, digestibility, processing behaviour, palatability and the rules in your market — and sourced to your specification.

Ingredientsimages/pd-novel-proteins.jpg · 1600×1200
Insightsimages/article-11.jpg · 1600×1200

Market insights from Guires PNL scientists

Regulation updates, the latest research, recalls and market trends that shape commercial manufacturing — written by our formulation, testing and regulatory teams.

FAQs

Common questions.

Do you own the factories?

No. Commercial manufacturing runs through GMP-certified partner manufacturers; we select, transfer and support.

Can you use my existing manufacturer?

Yes. We can transfer the product to a manufacturer you already work with.

Who owns the process data?

Clients own their project data; ownership of formulas and transfer packages is agreed in the contract.

Client Testimonials · Pilot Manufacturing

What our clients say.

Clients in the USA, UK and UAE on working with Guires PNL. Names are withheld at clients’ request.

“Scaling our dry kibble recipe from lab batches to pilot production was our biggest unknown. Process validation and batch trials proved the product stayed consistent at scale before we approached a co-manufacturer.”
USAHead of Product DevelopmentUnited States
“They helped us define processing conditions and batch specifications for our wet food range ahead of commercial production. The validation data made scale-up planning noticeably faster.”
UKR&D DirectorUnited Kingdom
“Moving our treat line into pilot manufacturing raised questions about equipment, batch sizes and technology transfer. Their team resolved each one, so we entered full production well prepared.”
UAEManufacturing Operations ManagerUnited Arab Emirates

Planning commercial scale-up & manufacturing?

Tell us your product, your question and your market — our scientists will come back with a study design and next steps.

FEDIAFAAFCO

Every Guires PNL product is formulated to comply with the FEDIAF Nutritional Guidelines and the AAFCO Dog and Cat Food Nutrient Profiles. Neither body issues certificates to manufacturers, so compliance is verified independently against their published standards — and every product comes with a complete documentation package for regulatory submissions in the EU, US, Australia and Asian markets.

How we verify compliance →
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